芦丁对骨肉瘤生长和转移的体内外抑制作用

李想, 魏鸣, 吴文曦, 罗小琴, 姚彪, 伍思宇

Inhibitory effect of rutin on the growth and metastasis of osteosarcoma in vitro and in vivo

LI Xiang, WEI Ming, WU Wenxi, LUO Xiaoqin, YAO Biao, WU Siyu

图6 芦丁对骨肉瘤体内移植瘤生长的影响 Note： A. Tumor image. B. Tumor weight. C. Tumor volume. D. The expression of Ki67 detected by immunohistochemistry and statistical analysis of Ki67-positive cell rate. E. The expression of VEGF detected by immunohistochemistry and statistical analysis of VEGF-positive cell rate. F. The tumor cell apoptosis detected by TUNEL and analysis of apoptosis rate. ①P<0.001, compared with the control group.

Fig 6 Effect of rutin on the growth of osteosarcoma xenograft tumors in vivo