腹部脂肪面积与2型糖尿病患者胰岛β细胞第一时相分泌功能的关系

陆佳萍, 刘醒, 张林杉, 赵琳, 张敏, 李小英, 刘玥隽

Relationship between abdominal fat area and first-phase insulin secretion function of pancreatic β-cells in patients with type 2 diabetes

LU Jiaping, LIU Xing, ZHANG Linshan, ZHAO Lin, ZHANG Min, LI Xiaoying, LIU Yuejun

表1 胰岛分泌功能残存组和衰竭组临床资料及生化指标比较

Tab 1 Comparison of clinical and biological parameters between the insulin secretion function-preserved group and the depleted group

Item Preserved group (n=74) Depleted group (n=46) P value Age/year 54.0 (47.8, 64.0) 60.0 (50.5, 67.3) 0.096 Male/n(%) 52 (70.3) 26 (56.5) 0.125 Hypertension/n(%) 36 (48.6) 26 (56.5) 0.401 Dyslipidemia/n(%) 64 (86.5) 37 (80.4) 0.529 Abdominal obesity/n(%) 57 (77.0) 22 (47.8) <0.001 MetS score/n(%) 0.036 1 point or 2 points 15 (20.3) 19 (41.3) 3 points 31 (41.9) 12 (26.1) 4 points 28 (37.8) 15 (32.6) Diabetes duration/year 5.00 (0, 10.00) 10.00 (4.00, 20.00) <0.001 Treated with insulin/n(%) 21 (28.4) 21 (45.7) 0.054 Waist circumference/cm 93.20±8.46 88.47±8.75 0.004 Hip circumference/cm 99.74±6.05 94.98±7.83 <0.001 Waist-to-hip ratio 0.93±0.06 0.93±0.06 0.848 Weight/kg 74.22±10.75 67.40±11.33 0.001 BMI/(kg·m-2) 25.46 (24.10, 27.75) 23.71 (22.70, 25.99) 0.002 FPG/(mmol·L-1) 7.60 (6.30, 9.90) 8.15 (6.28, 10.90) 0.492 Fasting insulin/(pmol·L-1) 64.58 (38.19, 88.89) 42.36 (18.40, 64.24) 0.006 Fasting C-peptide/(ng·mL-1) 2.31 (1.62, 2.86) 1.78 (1.09, 2.26) 0.003 HOMA-IR 2.73 (1.96, 4.60) 1.82 (1.19, 2.63) 0.016 HOMA-β 44.64 (25.29, 73.03) 26.32 (8.80, 66.71) 0.082 2 h-PG/(mmol·L-1) 11.10 (8.90, 14.20) 11.20 (9.05, 14.45) 0.779 2 h-insulin/(pmol·L-1) 165.58 (81.94, 254.17) 138.89 (57.99, 211.46) 0.268 2 h-C-peptide/(ng·mL-1) 4.61 (2.89, 6.43) 3.29 (2.10, 5.03) 0.120 GA/% 22.05 (17.93, 28.55) 25.80 (20.20, 31.20) 0.086 HbA1C/% 9.35 (7.68, 10.78) 9.90 (8.45, 11.40) 0.089 ALT/(U·L-1) 18.50 (13.75, 33.50) 17.00 (10.75, 25.25) 0.075 AST/(U·L-1) 18.00 (14.00, 27.35) 15.00 (12.00, 23.25) 0.068 GGT/(U·L-1) 26.50 (18.75, 47.50) 22.00 (15.00, 32.50) 0.091 TBA/(μmol·L-1) 3.30 (2.15, 5.20) 3.10 (1.80, 4.33) 0.444 Scr/(μmol·L-1) 68.00 (60.00, 81.00) 68.50 (56.75, 82.00) 0.885 eGFR/[mL·(min·1.73m2)-1] 98.00 (83.00, 108.00) 92.00 (80.00, 102.75) 0.232 UA/(μmol·L-1) 337.00 (274.00, 403.00) 284.00 (241.75, 354.00) 0.049 24 h-UAE/[mg·(24 h)-1] 15.85 (8.99, 24.19) 19.75 (11.26, 32.99) 0.125 TC/(mmol·L-1) 4.57±1.11 4.56±0.92 0.956 TAG/(mmol·L-1) 1.62 (1.27, 2.26) 1.55 (1.05, 2.17) 0.473 LDL-C/(mmol·L-1) 2.67±0.96 2.66±0.86 0.934 NHDL-C/(mmol·L-1) 3.34 (2.82, 4.17) 3.52 (2.64, 4.04) 0.987 HDL-C/(mmol·L-1) 1.05 (0.91, 1.18) 1.08 (0.96, 1.24) 0.308 FFA/(mmol·L-1) 0.54 (0.43, 0.61) 0.47 (0.33, 0.62) 0.088 Adipo-IR 4.22 (2.71, 7.11) 3.11 (1.45,6.25) 0.040 FT3/(pmol·L-1) 4.50 (4.10, 4.90) 4.20 (3.65, 4.55) 0.001 FT4/(pmol·L-1) 16.59±2.78 16.99±2.10 0.405 TSH/(mIU·L-1) 1.76 (1.10, 2.08) 1.43 (1.06, 2.36) 0.359 CRP/(mg·L-1) 1.05 (0.53, 2.08) 0.90 (0.58, 2.25) 0.871 SAA/(mg·L-1) 3.50 (3.33, 4.25) 3.50 (3.20, 5.43) 0.993 ESR/(mm·h-1) 7.00 (4.00, 13.00) 10.00 (3.50, 15.00) 0.385 IMT≥1.0 mm/n(%) 14 (22.2) 10 (26.3) 0.640 baPWV/(m·s-1) 15.41 (13.57, 17.83) 17.63 (14.18, 22.19) 0.009 ABI 1.16 (1.08, 1.22) 1.12 (1.06, 1.17) 0.033 CAP/(dB·m-1) 275.68±52.84 267.00±59.18 0.478 LSM/kPa 5.65 (4.50, 6.55) 5.25 (4.33, 6.23) 0.415 VFA/cm2 81.91±30.81 64.50±29.21 0.003 SFA/cm2 186.30 (156.40, 227.70) 151.95 (127.15, 190.55) <0.001