空气污染与阿尔茨海默病因果关联的两样本孟德尔随机化研究

张迎迎, 张俊瑶, 宋际伟, 王声杰, 姚俊岩

Two-sample Mendelian randomization study on the causal association between air pollution and Alzheimer′s disease

ZHANG Yingying, ZHANG Junyao, SONG Jiwei, WANG Shengjie, YAO Junyan

表1 空气污染与AD因果关联研究的样本量、SNP数量及人群信息

Tab 1 Sample size， SNP counts and population information for causal association study between air pollution and AD

Exposure/outcome Dataset Sample size/n Number of SNPs/n Population Publication year PM2.5 ukb-b-10 817 423 796 participants 9 851 867 European 2018 PM2.5-10 ukb-b-12 963 423 796 participants 9 851 867 European 2018 PM10 ukb-b-589 455 314 participants 9 851 867 European 2018 Nitrogen dioxide ukb-b-2 618 456 380 participants 9 851 867 European 2018 Nitrogen oxides ukb-b-12 417 456 380 participants 9 851 867 European 2018 AD NG00053 25 580 cases and 48 466 controls 7 055 881 (stage 1) and 11 632 (stage 2) European 2013