空气污染与阿尔茨海默病因果关联的两样本孟德尔随机化研究

张迎迎, 张俊瑶, 宋际伟, 王声杰, 姚俊岩

Two-sample Mendelian randomization study on the causal association between air pollution and Alzheimer′s disease

ZHANG Yingying, ZHANG Junyao, SONG Jiwei, WANG Shengjie, YAO Junyan

表2 5种空气污染指标与AD发病风险之间因果关系的MR分析

Tab 2 MR analysis of the causal relationship between five air pollution indicators and the risk of AD

Exposure	Outcome	SNP/n	MR method	P value	OR value	95%CI	Pleiotropy P value	Heterogeneity P value
PM_2.5	AD	48	MR-Egger	0.874	0.863	0.141‒5.295	0.278	0.453
			WM	0.031	2.186	1.073‒4.453
			IVW	<0.001	2.302	1.421‒3.729		0.444
			Simple mode	0.192	2.777	0.615‒12.550
			Weighted mode	0.291	2.175	0.524‒9.024
PM_2.5-10	AD	4	MR-Egger	0.432	0.905	0.741‒1.106	0.300	0.967
			WM	0.890	0.992	0.878‒1.119
			IVW	0.664	1.023	0.924‒1.131		0.576
			Simple mode	0.945	1.007	0.828‒1.225
			Weighted mode	0.782	0.980	0.860‒1.116
PM₁₀	AD	4	MR-Egger	0.432	0.905	0.741‒1.106	0.300	0.967
			WM	0.890	0.992	0.878‒1.119
			IVW	0.664	1.023	0.924‒1.131		0.576
			Simple mode	0.945	1.007	0.828‒1.225
			Weighted mode	0.782	0.980	0.860‒1.116
Nitrogen dioxide	AD	84	MR-Egger	0.973	0.978	0.271‒3.531	0.705	0.428
			WM	0.303	1.354	0.756‒2.423
			IVW	0.284	1.239	0.837‒1.834		0.457
			Simple mode	0.216	2.512	0.591‒10.670
			Weighted mode	0.294	2.063	0.538‒7.910
Nitrogen oxides	AD	67	MR-Egger	0.682	0.703	0.131‒3.764	0.563	0.206
			WM	0.892	0.960	0.536‒1.721
			IVW	0.567	1.137	0.733‒1.762		0.223
			Simple mode	0.444	0.578	0.144‒2.330
			Weighted mode	0.538	0.649	0.165‒2.549