长非编码RNA LINC00467在肺腺癌中的表达及其影响肺腺癌进展的机制研究

郭琳琰, 张海龙, 郑超, 雷鸣

Expression of long noncoding RNA LINC00467 and its mechanism in affecting lung adenocarcinoma progression

GUO Linyan, ZHANG Hailong, ZHENG Chao, LEI Ming

图6 敲低LINC00467对NF-κB信号通路的影响 Note： A. Volcano plot of DEGs based on RNA-seq data. B. Heatmap of DEGs from RNA-seq analysis. C. Hallmark gene sets enrichment analysis of DEGs based on RNA-seq data. D. Detection of the genes enriched in the NF-κB pathway by qPCR. E. Detection of NF-κB p65 and p-NF-κB p65 by Western blotting. F/G. Relative expression levels of NF-κB p65 (F) and p-NF-κB p65 (G). E2F—transcription factor E2F; TGFβ—transforming growth factor β; NFKBIA—NF-κB inhibitor α; RELB—NF-KB Subunit; SERPINE1—serpin family E member 1; TRAF1—TNF receptor-associated factor 1. ①P<0.001, compared with the control group.

Fig 6 Effect of LINC00467 knockdown on NF-κB signaling pathway