CAR-T细胞治疗自身免疫性疾病的研究述评

王雪懿, 李本尚

Review of CAR-T cell therapy for autoimmune diseases

WANG Xueyi, LI Benshang

表1 CAR-T细胞治疗AID的临床前试验

Tab 1 Preclinical trials of CAR-T cell treatment for AIDs

Disease	Target antigen	CAR-T cell type	Experimental model	Reference
SLE	CD19	anti-CD19 CAR-T	MRL/lpr mice, (NZB×NZW) F1 mice	[15]
SLE	CD19	anti-CD19 CAR-T	MRL/lpr mice	[16]
RA	antigenic FITC peptide	anti-FITC CAR-T	CIA mice	[22]
RA	CⅡ-specific autoimmune CD4⁺ T cells	DR1-CII CAR-T	CIA mice	[23]
T1DM	I-A^g7-B:9-23(R3) antigen complex	mAb287 CAR-T	NOD mice	[27]
	Insulin or IGPR-specific CD8⁺ T cells	Insulin/IGPR-reactive CAR-T	NOD mice	[28]
	Pancreatic β cell-specific CD4⁺ T cells	^5MCAR-CTLs	NOD mice	[29]
	Insulin	Insulin-specific CAR-Treg	NOD mice	[30]
	HPi2	HPi2 CAR-Treg	Human pancreatic β cell line, mouse β cell line	[31]
PV	Dsg3-specific B cells	Dsg3 CAAR-T	NSG-PV hybridoma model	[32]
PV	Dsg3-specific B cells	Dsg3 CAAR-T	Active immune PV mice, NSG-PV hybridoma model	[33]
UC	CEA	CEA CAR-Treg	CEA-transgenic mice, AOM-DSS-CRC model	[34]
	TNP	TNP-TPCR Treg	hapten-COL model	[35]
	FliC	FliC CAR-Treg	DNBS-COL NSG model	[36]
MS	MOG	CARαMOG-FoxP3-Treg	EAE mice	[37]
	MOG and MBP	MOG/MBP CAR-Tregs	EAE mice	[38]
	CD19	anti-CD19 CAR-T	EAE mice	[39]
	CD19	anti-CD19 CAR-T	OSE mice	[40]
GVHD	HLA-A2	HLA-A2 CAR-Treg	GVHD mice	[41]
ANCA-AVV	CD19	anti-CD19 CAR-T	MPO-AVV mice	[42]
MG	anti-MuSK B cells	MuSK CAAR-T	NSG Nalm-6 xenografted mice, syngeneic MuSK EAMG mice	[43]
NMDAR encephalitis	NMDAR autoantibodies	NMDAR CAAR-T	NSG xenograft model	[44]