LINC01123通过结合ENO1促进胃癌的增殖和糖酵解

张舒琼, 柯星, 赵兴贺, 陈晓翠, 郑浩东, 陈惠, 沈立松, 杨俊瑶

LINC01123 promotes proliferation and glycolysis of gastric cancer via binding to ENO1

ZHANG Shuqiong, KE Xing, ZHAO Xinghe, CHEN Xiaocui, ZHENG Haodong, CHEN Hui, SHEN Lisong, YANG Junyao

图1 LINC01123在胃癌中的高表达及不良预后关联 Note： A/B. Venn diagrams illustrating the overlap of upregulated (A) and downregulated (B) long non-coding RNAs (lncRNAs) identified in the TCGA-STAD, GSE95667, and GSE99416 datasets. C. Volcano plot depicting differentially expressed lncRNAs in the TCGA-STAD dataset. D. LINC01123 expression was significantly upregulated in gastric cancer cell lines. E. LINC01123 expression was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. F. Expression of LINC01123 across different cancer types in TCGA. G. UALCAN analysis showing that LINC01123 was upregulated in STAD tissues. H. LINC01123 expression in different TNM stages of gastric cancer. I. LINC01123 expression profile based on tumor histology. J. Kaplan-Meier analysis showing that high LINC01123 expression was associated with poor overall survival in TCGA-STAD patients. K. Gene set enrichment analysis (GSEA) comparing high and low LINC01123 expression groups. ①P=0.011, ②P=0.002, ③P=0.007, compared with GES-1; ④P<0.001, ⑤P=0.004, compared with Normal.

Fig 1 Overexpression of LINC01123 in gastric cancer and its association with poor prognosis