LINC01123通过结合ENO1促进胃癌的增殖和糖酵解

张舒琼, 柯星, 赵兴贺, 陈晓翠, 郑浩东, 陈惠, 沈立松, 杨俊瑶

LINC01123 promotes proliferation and glycolysis of gastric cancer via binding to ENO1

ZHANG Shuqiong, KE Xing, ZHAO Xinghe, CHEN Xiaocui, ZHENG Haodong, CHEN Hui, SHEN Lisong, YANG Junyao

图2 LINC01123敲低对胃癌细胞体外增殖、迁移和侵袭的抑制作用 Note： A. qRT-PCR assay demonstrated that sh-LINC01123 lentivirus effectively altered LINC01123 expression. B/C. CCK-8 assay (B) and colony-formation assay (C) showed the effects of knockdown of LINC01123 on cell proliferation. D/E. Wound healing assay (D) and Transwell migration assay (E) were performed to detect the migration ability of MKN-45 and AGS cells after knockdown of LINC01123. F. Transwell invasion assay was conducted to assess the effects of LINC01123 knockdown on cell invasion. ①P=0.030, ②P=0.011, ③P<0.001, ④P=0.010, ⑤P=0.020, ⑥P=0.009, ⑦P=0.005, ⑧P=0.007, compared with sh-NC.

Fig 2 Inhibitory effects of LINC01123 knockdown on gastric cancer cell proliferation, migration, and invasion in vitro