LINC01123通过结合ENO1促进胃癌的增殖和糖酵解

张舒琼, 柯星, 赵兴贺, 陈晓翠, 郑浩东, 陈惠, 沈立松, 杨俊瑶

LINC01123 promotes proliferation and glycolysis of gastric cancer via binding to ENO1

ZHANG Shuqiong, KE Xing, ZHAO Xinghe, CHEN Xiaocui, ZHENG Haodong, CHEN Hui, SHEN Lisong, YANG Junyao

图3 LINC01123过表达对胃癌细胞体外增殖、迁移和侵袭的促进作用 Note： A. qRT-PCR assay demonstrated that LINC01123 overexpression lentivirus effectively altered LINC01123 expression. B/C. CCK-8 assay (B) and colony-formation assay (C) showed the effects of overexpression of LINC01123 on cell proliferation. D. Wound healing assay was performed to detect the migration ability of MKN-45 and HGC-27 cells after the overexpression of LINC01123. E. Transwell migration assay was performed to detect the migration ability of MKN-45 and HGC-27 cells after the overexpression of LINC01123. F. Transwell invasion assay was conducted to assess the effects of knockdown or overexpression of LINC01123 on cell invasion. ①P<0.001, ②P=0.006, ③P=0.007, ④P=0.010, ⑤P=0.020, ⑥P=0.009, ⑦P=0.030, ⑧P=0.002, ⑨P=0.005, compared with Vector.

Fig 3 Promotive effects of LINC01123 overexpression on gastric cancer cell proliferation, migration, and invasion in vitro