CD10+中性粒细胞通过SELPLG-SELL通路促进黏膜恶性黑色素瘤CD8+ T细胞耗竭

郝美灵, 马彦妮, 马旭辉, 张燕捷, 曾汉林, 陈善双

CD10+ neutrophils promote CD8+ T-cell depletion in mucosal malignant melanoma through the SELPG-SELL pathway

HAO Meiling, MA Yanni, MA Xuhui, ZHANG Yanjie, ZENG Hanlin, CHEN Shanshuang

图1 MM与CM单细胞图谱 Note： A. UMAP map of cell types of mucosal melanosis and cutaneous melanosis. B. Bubble heatmap of the expression of canonical marker genes corresponding to each cell type. C. UMAP map of the expression of the marker genes for the indicated cell subtypes. D/E. Distribution and comparative analysis of immune cells in mucosal melanosis and cutaneous melanosis (MM for mucosal melanosis, CM for cutaneous melanosis) in bar plot (D) and box plot (E).

Fig 1 Single-cell mapping of mucosal malignant melanoma and cutaneous malignant melanoma