CD10+中性粒细胞通过SELPLG-SELL通路促进黏膜恶性黑色素瘤CD8+ T细胞耗竭

郝美灵, 马彦妮, 马旭辉, 张燕捷, 曾汉林, 陈善双

CD10+ neutrophils promote CD8+ T-cell depletion in mucosal malignant melanoma through the SELPG-SELL pathway

HAO Meiling, MA Yanni, MA Xuhui, ZHANG Yanjie, ZENG Hanlin, CHEN Shanshuang

图5 黏膜与皮肤恶性黑色素瘤微环境中T细胞-中性粒细胞互作网络特征 Note： A/B. The differences in the intensity of cellular interactions (A) and the number of interactions (B) in mucosal and skin mellanism are shown in red for upreluation and in blue for downregulation. C. Percentage stacked histogram of the overall information flow of each signaling pathway in mucosal and skin dark. D SELPLG-SELL-mediated cellular interaction network in mucosal and cutaneous malignant melanoma.

Fig 5 Characterization of T cell-neutrophil interaction networks in the microenvironment of mucosal and cutaneous malignant melanoma