CD10+中性粒细胞通过SELPLG-SELL通路促进黏膜恶性黑色素瘤CD8+ T细胞耗竭

郝美灵, 马彦妮, 马旭辉, 张燕捷, 曾汉林, 陈善双

CD10+ neutrophils promote CD8+ T-cell depletion in mucosal malignant melanoma through the SELPG-SELL pathway

HAO Meiling, MA Yanni, MA Xuhui, ZHANG Yanjie, ZENG Hanlin, CHEN Shanshuang

图6 黏膜与皮肤恶性黑色素瘤微环境中TAN2_CD10+ 中性粒细胞亚群由炎症富集 Note： A. UMAP map of cell types in mucosal health, mucosal inflammation, and mucosal melanoma. B. UMAP map of sample distribution in mucosal health, mucosal inflammation, and mucosal melanoma. C. Gene expression spectrum of cell types in mucosal health, mucosal inflammation, and mucosal melanoma. D. UMAP map of neutrophil distribution groups in mucosal health, mucosal inflammation, and mucosal melanoma. E. MDSC gene set score of neutrophil subgroups in mucosal health and mucosal inflammation. F. Cell proportion of neutrophil subgroups in mucosal health and mucosal inflammation.

Fig 6 TAN2_CD10+ neutrophil subpopulation is enriched by inflammation in the microenvironment of mucosal and cutaneous malignant melanoma