ABCA7在结直肠癌中的临床价值及转录调控机制

孙瑞状, 乔坤朋, 李璞, 徐小莲, 孟俊

Clinical value and transcriptional regulatory mechanism of ABCA7 in colorectal cancer

SUN Ruizhuang, QIAO Kunpeng, LI Pu, XU Xiaolian, MENG Jun

图1 ABCA7 单细胞测序数据展示CRC恶性细胞中 ABCA7 的表达分布 Note： A. Subgroup division of multiple CRC single-cell sequencing datasets, displaying the expression distribution of ABCA7 in different CRC cell subgroups. B. Identification of CRC and microenvironmental cell types (including endothelial cells, intestinal epithelial cells, malignant cells, etc.) using t-SNE dimensionality reduction clustering. C. Pie charts presenting the proportion of different cell types in CRC samples, reflecting the dominance of malignant cells. D. t-SNE visualization of ABCA7 expression distribution in CRC cells, with color gradients indicating differences in expression levels. E. Heatmap analysis of differentially expressed genes in CRC, showing gene expression patterns in subgroups and screening for differential genes. F. t-SNE display of the expression distribution of key CRC genes (CEACAM5, TP53, BRAF, etc.) in cells.

Fig 1 Single-cell sequencing data of ABCA7 showing the expression distribution of ABCA7 in malignant cells of CRC