ABCA7在结直肠癌中的临床价值及转录调控机制

孙瑞状, 乔坤朋, 李璞, 徐小莲, 孟俊

Clinical value and transcriptional regulatory mechanism of ABCA7 in colorectal cancer

SUN Ruizhuang, QIAO Kunpeng, LI Pu, XU Xiaolian, MENG Jun

图3 ABCA7 在CRC中mRNA水平的表达及其对CRC细胞生长的影响 Note： A. Violin plot comparing tumor and normal tissues, showing high mRNA expression of ABCA7 in CRC. B. ROC curve evaluating the diagnostic efficacy of ABCA7 mRNA for CRC, with an AUC of 0.686 (95% CI 0.626‒0.747). C. CRISPR screening results showing CRISPR scores corresponding to different sgRNAs, with CRISPR score<0 suggesting that ABCA7 promotes CRC cell growth.

Fig 3 mRNA expression level of ABCA7 in CRC and its effect on CRC cell growth