ABCA7在结直肠癌中的临床价值及转录调控机制

孙瑞状, 乔坤朋, 李璞, 徐小莲, 孟俊

Clinical value and transcriptional regulatory mechanism of ABCA7 in colorectal cancer

SUN Ruizhuang, QIAO Kunpeng, LI Pu, XU Xiaolian, MENG Jun

图6 ABCA7 与CRC中高表达的 ZBTB33 和 NKRF 的共表达分析 Note： A. Pearson and Spearman analyses screening genes co-expressed with ABCA7 (r>0.7, P<0.05. e.g., ZBTB33, NKRF), with scatter plots showing expression correlation. B. mRNA expression of ZBTB33 and NKRF in CRC tumor tissues (purple) vs normal tissues (blue), showing higher expression in tumor tissues. C. Survival curves indicating a higher overall survival probability in CRC patients with low ZBTB33 and NKRF expression (ZBTB33: HR=0.80, P=0.263; NKRF: HR=1.14, P=0.517), reflecting the association between co-expressed genes and prognosis. D. Knockout experiments showing downregulated ABCA7 expression after NKRF and ZBTB33 knockout, revealing their transcriptional regulatory effect on ABCA7.

Fig 6 Co-expression analysis of ABCA7 with highly expressed ZBTB33 and NKRF in CRC