血红蛋白诱导心肌细胞铁死亡及Basigin的调控机制研究

李文丽, 钟方元, 赵怡超, 金力行, 雷杰, 石瑶, 卜军, 葛恒

Mechanisms of Basigin regulation in hemoglobin-induced cardiomyocyte ferroptosis

LI Wenli, ZHONG Fangyuan, ZHAO Yichao, JIN Lixing, LEI Jie, SHI Yao, PU Jun, GE Heng

图1 Hb诱导H9c2心肌细胞损伤且呈浓度依赖性 Note： A. Flow cytometry analysis of PI-positive H9c2 cardiomyocytes after treatment with different concentrations of Hb for 24 h. B. Quantitative analysis of PI-positive rates in H9c2 cardiomyocytes. C. WST-1 assay to detect the viability of H9c2 cardiomyocytes after treatment with different concentrations of Hb. ①P=0.044, ②P<0.001, ③P=0.020.

Fig 1 H9c2 cardiomyocyte injury induced by Hb in a concentration-dependent manner