血红蛋白诱导心肌细胞铁死亡及Basigin的调控机制研究

李文丽, 钟方元, 赵怡超, 金力行, 雷杰, 石瑶, 卜军, 葛恒

Mechanisms of Basigin regulation in hemoglobin-induced cardiomyocyte ferroptosis

LI Wenli, ZHONG Fangyuan, ZHAO Yichao, JIN Lixing, LEI Jie, SHI Yao, PU Jun, GE Heng

图3 铁死亡抑制剂对Hb诱导的H9c2心肌细胞损伤的影响 Note： A. WST-1 assay to detect the effects of different cell death inhibitors on the viability of H9c2 cardiomyocytes induced by Hb. B. Flow cytometry analysis of the effect of Fer-1 on PI-positive rate in Hb-treated H9c2 cardiomyocytes. C. Quantitative analysis of the flow cytometry results. ①P<0.001.

Fig 3 Effect of the ferroptosis inhibitor on Hb-induced H9c2 cardiomyocyte injury