肠道微生物群与心血管疾病的因果关系评价：双向孟德尔随机化分析
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马会华, 闫奎坡, 刘刚, 徐亚洲, 张磊, 孙彦琴
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Causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis
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MA Huihua, YAN Kuipo, LIU Gang, XU Yazhou, ZHANG Lei, SUN Yanqin
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表2 基于IVW法分析肠道微生物与CVD的因果关系
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Tab 2 Causal relationship between gut microbiota and CVD based on IVW method
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| Outcome | Exposure | MR method | SNP/n | β | se | OR (95%CI) | P value | Correct causal direction | P value (Steiger test) |
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| AF | | | | | | | | | | | Catenibacterium | IVW | 5 | 0.05 | 0.025 | 1.057 (1.005‒1.112) | 0.030 | True | 4.85×10-6 | | Victivallales | IVW | 8 | -0.06 | 0.023 | 0.939 (0.896‒0.984) | 0.008 | True | 1.52×10-6 | | Howardella | IVW | 10 | -0.06 | 0.019 | 0.939 (0.904‒0.977) | 0.001 | True | 3.04×10-5 | | Lachnospiraceae UCG008 | IVW | 11 | 0.04 | 0.025 | 1.051 (1.001‒1.104) | 0.047 | True | 2.52×10-7 | | Anaerostipes | IVW | 13 | -0.08 | 0.037 | 0.922 (0.857‒0.993) | 0.030 | True | 5.20×10-6 | | Bifidobacteriaceae | IVW | 11 | -0.08 | 0.034 | 0.916 (0.855‒0.980) | 0.011 | True | 1.42×10-5 | | Lentisphaeria | IVW | 8 | -0.06 | 0.024 | 0.936 (0.887‒0.983) | 0.003 | True | 3.96×10-6 | | Streptococcus | IVW | 15 | 0.08 | 0.039 | 1.089 (1.008‒1.177) | 0.029 | True | 9.37×10-6 | | Victivallis | IVW | 10 | 0.03 | 0.018 | 1.038 (1.001‒1.077) | 0.043 | True | 4.62×10-6 | | Odoribacter | IVW | 7 | -0.09 | 0.046 | 0.909 (0.831‒0.996) | 0.040 | True | 1.81×10-5 | | Intestinibacter | IVW | 15 | -0.06 | 0.031 | 0.933 (0.877‒0.993) | 0.028 | True | 2.28×10-6 | | Lentisphaerae | IVW | 9 | -0.07 | 0.022 | 0.926 (0.886‒0.968) | <0.001 | True | 5.06×10-6 | | Bifidobacteriales | IVW | 11 | -0.08 | 0.034 | 0.916 (0.855‒0.980) | 0.011 | True | 1.35×10-5 | | CAD | | | | | | | | | | | Lactobacillales | IVW | 15 | -0.08 | 0.032 | 0.919 (0.862‒0.980) | 0.010 | True | 9.28×10-7 | | Veillonellaceae | IVW | 19 | 0.06 | 0.026 | 1.065 (1.011‒1.122) | 0.018 | True | 1.21×10-5 | | Parabacteroides | IVW | 6 | -0.14 | 0.050 | 0.866 (0.784‒0.956) | 0.004 | True | 6.31×10-5 | | Lachnospiraceae | IVW | 17 | 0.09 | 0.038 | 1.094 (1.012‒1.183) | 0.023 | True | 7.23×10-6 | | Lachnoclostridium | IVW | 13 | 0.08 | 0.039 | 1.093 (1.011‒1.181) | 0.025 | True | 9.14×10-5 | | Oxalobacter | IVW | 11 | 0.05 | 0.020 | 1.062 (1.019‒1.106) | 0.004 | True | 6.05×10-6 | | Odoribacter | IVW | 7 | 0.14 | 0.047 | 1.160 (1.056‒1.275) | 0.001 | True | 6.42×10-7 | | Hypertension | | | | | | | | | | | Mollicutes RF9 | IVW | 13 | -0.16 | 0.068 | 0.851 (0.743‒0.974) | 0.019 | True | 7.23×10-5 | | Peptococcaceae | IVW | 9 | 0.20 | 0.086 | 1.230 (1.038‒1.458) | 0.016 | True | 2.07×10-5 | | Christensenellaceae R7 group | IVW | 10 | 0.19 | 0.100 | 1.218 (1.001‒1.483) | 0.049 | True | 9.97×10-5 | | Coriobacteriales | IVW | 14 | -0.21 | 0.085 | 0.803 (0.679‒0.950) | 0.010 | True | 0.001 | | Coriobacteriia | IVW | 14 | -0.21 | 0.085 | 0.803 (0.679‒0.950) | 0.010 | True | 0.002 | | Desulfovibrio | IVW | 10 | 0.15 | 0.062 | 1.167 (1.033‒1.318) | 0.012 | True | 0.007 | | Coriobacteriaceae | IVW | 14 | -0.21 | 0.085 | 0.803 (0.679‒0.950) | 0.010 | true | 0.007 | | Intestinibacter | IVW | 15 | -0.19 | 0.083 | 0.819 (0.696‒0.965) | 0.010 | True | 0.015 | | HF | | | | | | | | | | | Ruminococcaceae UCG009 | IVW | 12 | 0.06 | 0.030 | 1.107 (1.009‒1.137) | 0.022 | True | 6.12×10-6 | | Eubacterium oxidoreducens group | IVW | 4 | 0.11 | 0.043 | 1.117 (1.026‒1.215) | 0.010 | True | 3.26×10-5 | | Bacillales | IVW | 9 | -0.04 | 0.022 | 0.955 (0.913‒0.998) | 0.010 | True | 5.84×10-6 | | Selenomonadales | IVW | 12 | 0.10 | 0.044 | 1.106 (1.013‒1.208) | 0.023 | True | 1.53×10-5 | | Anaerostipes | IVW | 13 | -0.10 | 0.043 | 0.899 (0.825‒0.974) | 0.013 | True | 3.77×10-6 | | Negativicutes | IVW | 12 | 0.10 | 0.044 | 1.107 (1.014‒1.208) | 0.023 | True | 4.48×10-5 | | Eubacterium eligens group | IVW | 7 | 0.13 | 0.057 | 1.139 (1.019‒1.274) | 0.022 | True | 6.43×10-6 | | Flavonifractor | IVW | 5 | 0.13 | 0.053 | 1.144 (1.031‒1.270) | 0.011 | True | 1.06×10-5 |
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