肠道微生物群与心血管疾病的因果关系评价：双向孟德尔随机化分析

马会华, 闫奎坡, 刘刚, 徐亚洲, 张磊, 孙彦琴

Causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis

MA Huihua, YAN Kuipo, LIU Gang, XU Yazhou, ZHANG Lei, SUN Yanqin

表3 肠道微生物对CVD效应的异质性及水平多效性分析

Tab 3 Heterogeneity and horizontal pleiotropy analysis of the effect of gut microbiota on CVD

Outcome Exposure Cochran's Q MR-Egger intercept MR-Egger IVW Intercept P value Q value P value Q value P value AF Catenibacterium 0.370 0.946 0.488 0.974 0.010 0.753 Victivallales 3.948 0.683 4.155 0.761 0.005 0.665 Howardella 7.364 0.497 7.622 0.572 -0.006 0.624 Lachnospiraceae UCG008 8.051 0.528 8.162 0.612 0.004 0.747 Anaerostipes 12.334 0.339 12.561 0.402 -0.003 0.661 Bifidobacteriaceae 8.821 0.453 9.111 0.521 0.004 0.603 Lentisphaeria 3.948 0.683 4.155 0.761 0.005 0.665 Streptococcus 20.126 0.092 20.223 0.123 0.002 0.807 Victivallis 7.007 0.535 8.153 0.518 0.019 0.315 Odoribacter 3.621 0.605 4.634 0.591 0.010 0.360 Intestinibacter 14.962 0.309 17.041 0.253 0.010 0.203 Lentisphaerae 7.455 0.383 7.841 0.449 0.007 0.566 Bifidobacteriales 8.821 0.454 9.111 0.521 0.004 0.603 CAD Lactobacillales 13.551 0.406 14.344 0.424 -0.005 0.398 Veillonellaceae 14.934 0.528 1.741 0.495 0.005 0.241 Parabacteroides 4.608 0.329 4.742 0.448 0.005 0.750 Lachnospiraceae 21.818 0.112 24.485 0.079 -0.008 0.195 Lachnoclostridium 5.378 0.911 6.793 0.870 0.011 0.259 Oxalobacter 3.473 0.942 3.692 0.960 -0.006 0.650 Odoribacter 4.080 0.537 5.288 0.507 0.012 0.321 Hypertension Mollicutes RF9 3.784 0.975 0.711 0.877 <0.001 0.957 Peptococcaceae 5.131 0.643 0.331 0.178 0.055 0.358 Christensenellaceae R7 group 6.448 0.597 7.960 0.538 0.008 0.575 Coriobacteriales 8.827 0.717 9.577 0.728 0.012 0.575 Coriobacteriia 8.827 0.717 9.577 0.728 0.013 0.145 Desulfovibrio 3.323 0.912 7.960 0.538 0.222 0.253 Coriobacteriaceae 8.827 0.717 9.577 0.728 -0.020 0.403 Intestinibacter 19.114 0.119 21.572 0.087 -0.020 0.403 HF Ruminococcaceae UCG009 8.939 0.537 10.956 0.446 0.017 0.185 Eubacterium oxidoreducens group 2.451 0.293 2.483 0.478 -0.002 0.887 Bacillales 2.705 0.910 2.870 0.942 0.006 0.697 Selenomonadales 4.459 0.924 5.180 0.922 -0.007 0.415 Anaerostipes 9.973 0.532 10.057 0.610 -0.002 0.777 Negativicutes 4.459 0.924 5.180 0.922 -0.007 0.415 Eubacterium eligens group 1.547 0.907 6.428 0.376 -0.038 0.078 Flavonifractor 2.919 0.404 2.919 0.404 0.002 0.903