人胚胎干细胞向神经前体细胞分化的转录组与染色质可及性变化分析研究

李林颖, 蔡晓东, 童冉, 杨晨, 王志明, 贺潇宇, 马子越, 张丰, 李令杰, 周君梅

Analysis of transcriptome and chromatin accessibility changes during the differentiation of human embryonic stem cells into neural progenitor cells

LI Linying, CAI Xiaodong, TONG Ran, YANG Chen, WANG Zhiming, HE Xiaoyu, MA Ziyue, ZHANG Feng, LI Lingjie, ZHOU Junmei

图4 NPC分化过程中染色质可及性分析 Note： A. Volcano plot shows the peak signals of differentially open chromatin obtained from the ATAC-seq dataset. Differential open areas were defined as |log2FC| >0.585 and P<0.05. B. The differential region enrichment plot shows the average peak signal between different samples in the differentially upregulated region (left) and the differentially downregulated region (right) at the NPC stage. C. Differential region enrichment heatmap reveals peak signals within genomic region. D. GO analysis of genes associated with differentially open chromatin regions at the NPC stage. E. KEGG analysis of genes associated with differentially open chromatin regions at the NPC stage.

Fig 4 Chromatin accessibility analysis during NPC differentiation process