Fas相关死亡结构域蛋白促进头颈部鳞状细胞癌细胞增殖能力的机制研究

陈怡楠, 郑旸, 曾汉林, 雷鸣

Mechanism of Fas-associated protein with death domain in promoting proliferation of head and neck squamous cell carcinoma cells

CHEN Yinan, ZHENG Yang, ZENG Hanlin, LEI Ming

图5 FADD通过CUX1调控HNSCC细胞增殖
Note： A. Detection of CUX1 expression in HSC3 and Fadu cells after CUX1 knockout by Western blotting. B. Plate colony formation assay in Fadu^sg^CUX1 and HSC3^sg^CUX1 cells. C. Cell viability of Fadu^sg^CUX1 and HSC3^sg^CUX1 cells. D. Detection of P21 after CUX1 knockout in HSC3 and Fadu cells by Western blotting. E. The effect of CUX1 knockout on proliferation in stable-FADD-knockdown Fadu and HSC3 cells. ^①P=0.004, ^②P=0.008, ^③P=0.001, ^④P=0.001; ^⑤P<0.001, compared with the Fadu^MOCK group; ^⑥P<0.001 compared with the HSC3^MOCK group.

Fig 5 FADD regulates the proliferation of HNSCC cells through CUX1