利拉鲁肽改善非酒精性脂肪性肝病小鼠肝纤维化的作用及其机制

王仁杰, 祝超瑜, 方云云, 肖元元, 王倩倩, 宋雯婧, 魏丽

Effects and mechanisms of liraglutide in ameliorating liver fibrosis in NAFLD mice

WANG Renjie, ZHU Chaoyu, FANG Yunyun, XIAO Yuanyuan, WANG Qianqian, SONG Wenjing, WEI Li

图3 利拉鲁肽对小鼠肝脏脂肪变性与纤维化的影响 Note： A. Representative pictures of mouse livers. B. TAG levels in liver tissue of mice in each group. C. The ratio of liver to body weight in mice in each group. D. Liver tissue stained with Oil Red O. Double arrows indicate massive lipid droplets in the liver of MCD mice. A single arrow indicates that lipid droplets significantly reduced. E. Liver tissue stained with HE. Double arrows indicate massive hepatocyte ballooning and fat vacuoles in the liver of MCD mice. A single arrow indicates a significant reduction in hepatocyte ballooning degeneration and fat vacuoles. F. Liver tissue stained with Masson. Double arrows indicate massive blue collagen fibers in the liver of MCD mice. A single arrow indicates blue collagen fibers significantly reduced.

Fig 3 Effect of liraglutide on hepatic steatosis and fibrosis in mice