利拉鲁肽改善非酒精性脂肪性肝病小鼠肝纤维化的作用及其机制

王仁杰, 祝超瑜, 方云云, 肖元元, 王倩倩, 宋雯婧, 魏丽

Effects and mechanisms of liraglutide in ameliorating liver fibrosis in NAFLD mice

WANG Renjie, ZHU Chaoyu, FANG Yunyun, XIAO Yuanyuan, WANG Qianqian, SONG Wenjing, WEI Li

图6 利拉鲁肽对小鼠肝脏TGF-β通路的影响 Note： A. Expression of TGF-β, pSMAD3, SMAD3, and HSP90 proteins detected by Western blotting. B. The relative expression level of TGF-β mRNA in the liver of mice. C/D. The relative expression levels of TGF-β (C) and pSMAD3/SMAD3 (D) proteins in the liver of mice. E. Working plot of liraglutide decreasing the TGF-β/smad3 signaling and reducing the expression of FN, α-SMA, and COL1A.

Fig 6 Effect of liraglutide on indices of liver TGF-β pathway in mice