阻塞性睡眠呼吸暂停与脑成像衍生表型的双向孟德尔随机化研究

张慧华, 干静, 侯媌媌, 卢娜

Bidirectional Mendelian randomization study of the relationship between brain imaging-derived phenotypes and obstructive sleep apnea

ZHANG Huihua, GAN Jing, HOU Miaomiao, LU Na

图1 IDP与OSA双向MR分析流程 Note： 1—Relevance assumption (the selected instrumental variables must be associated with the exposure); 2—Independence assumption (the selected instrumental variables were not associated with potential confounders); 3—Exclusion restriction assumption (the instrumental variables affected the outcome only through their effect on the exposure). IV—instrumental variable.

Fig 1 Workflow of bidirectional MR analysis between IDPs and OSA