铅毒性的表观遗传学机制研究进展

张欣欣, 颜崇淮

Advances in epigenetic mechanisms of lead toxicity

ZHANG Xinxin, YAN Chonghuai

表1 铅暴露对miRNA的调控及其相关效应

Tab 1 Regulation of miRNA by Pb exposure and its related effects

Gene Expression change Sample type Effect Reference miR-155/miR-221 Upregulated Peripheral blood samples from adults Cell apoptosis, cell proliferation, and cytokine production PMID: 32902755 miR-146a Upregulated Peripheral blood samples from adults Inhibition of inflammatory factor release and cell apoptosis PMID: 36274319 miR-106b-56p Upregulated HT-22 and PC12 cell lines Decreased XIAP levels and cell viability PMID: 32344020 miR-378a-3p Upregulated HT-22 cell line Reduced GSH and increased lipid ROS levels PMID: 35588615 miR-143-5p Downregulated Fibroblast samples Regulation of dysfunction of interstitial fibroblasts PMID: 35485286 miR-106b/miR-124/miR-34c Upregulated Cerebral cortex tissue samples Induced neurotoxicity and learning/memory impairment PMID: 29614648/27293183 miR-34b Upregulated Hippocampal tissue samples Induced developmental neuropsychiatric dysfunction PMID: 35367965