不伴糖尿病的高血压患者血清骨诱导因子与肾功能及血压的关系
翟文慧, 黄绮芳, 陈怡琳, 李晓东, 王继光

Serum osteoglycin level in relation to renal function and blood pressure in non-diabetic patients with hypertension
ZHAI Wenhui, HUANG Qifang, CHEN Yilin, LI Xiaodong, WANG Jiguang
表1 患者基本特征
Tab 1 Characteristics of the patients
Characteristic

Renal dysfunction group

(n=36)

Normal renal function group

(n=38)

t/χ2 valueP value
Age/year53.5±10.450.8±11.11.070.287
Body mass index/(kg·m-2)26.0±3.525.3±3.20.890.375
Clinic blood pressure/mmHg
Systolic145.6±22.6142.0±19.30.740.459
Diastolic87.8±17.485.9±14.90.520.607
Ambulatory blood pressure/mmHg
24-hour systolic137.2±20.0133.1±15.11.010.318
24-hour diastolic87.1±15.184.8±11.20.760.453
Pulse rate/(beats·min-1)73.5±8.574.7±10.4-0.500.615
Total-to-HDL cholesterol ratio4.58±1.274.21±1.091.360.178
Serum LDL cholesterol/(mmol·L-1)3.10±0.752.95±0.800.800.428
Plasma fasting glucose/(mmol·L-1)5.48±0.635.59±1.07-0.510.609
eGFR/[mL·(min·1.73 m2)-1]73.4±13.8103.6±9.6-10.88<0.001
Serum uric acid/(µmol·L-1)399.7±100.2311.0±92.43.96<0.001
Serum hsCRP/(mg·L-1)0.99 (0.68‒2.02)0.71 (0.42‒1.79)0.820.414
Serum OGN concentration/(ng·mL-1)2.55±1.302.45±1.010.380.708
Female/n(%)16 (44.4)19 (50.0)0.2290.632
Current smoking/n(%)12 (33.3)13 (34.2)0.0060.936
Current alcohol intake/n(%)6 (16.7)7 (18.4)0.0390.843
History of cardiovascular diseases/n(%)3 (8.3)6 (15.8)0.9620.327
Use of antihypertensive drugs/n(%)36 (100.0)37 (97.4)0.9600.327
Angiotensin-converting enzyme inhibitors9 (25.0)6 (15.8)0.9700.325
Angiotensin-receptor blockers16 (44.4)22 (57.9)1.3390.247
Calcium channel blockers31 (86.1)29 (76.3)1.1560.282
Diuretics7 (19.4)5 (13.2)0.5380.463
β-blockers15 (41.7)15 (39.5)0.0370.848
Others7 (19.4)9 (23.7)0.1960.658
Albuminuria/n(%)10 (27.8)0 (0)12.205<0.001