两样本孟德尔随机化分析血浆磷脂酰乙醇胺水平与结直肠腺癌发病风险的关系
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徐苓, 皇甫昱婵, 沈立松, 马妍慧
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Causal association between plasma phosphatidylethanolamine and risk of colorectal adenocarcinoma: a two-sample Mendelian randomization study
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XU Ling, HUANGFU Yuchan, SHEN Lisong, MA Yanhui
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表1 PE用于TSMR分析的工具变量
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Tab 1 Instrumental variables for TSMR analysis of PE
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| SNP | Chr | Position | Effect allele | Other allele | EAF | β | SE | P value | Nearby gene | R2 | F value | SteigerP value |
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| rs102275 | 11 | 61790331 | C | T | 0.35 | -0.18 | 0.01 | 4.40×10-66 | TMEM258 | 0.020 9 | 202.64 | 8.47×10-57 | | rs10781444 | 9 | 77534256 | C | T | 0.80 | 0.06 | 0.01 | 3.10×10-6 | GNA14 | 0.001 6 | 14.69 | 1.48×10-5 | | rs1087299 | 4 | 184305068 | C | T | 0.33 | 0.05 | 0.01 | 5.41×10-6 | MYL12BP2 | 0.001 5 | 14.17 | 9.06×10-6 | | rs11254897 | 10 | 6942964 | G | A | 0.06 | 0.09 | 0.02 | 6.40×10-6 | LOC105376387 | 0.001 5 | 13.79 | 3.20×10-5 | | rs1532085 | 15 | 58391167 | G | A | 0.61 | -0.11 | 0.01 | 3.01×10-27 | ALDH1A2 | 0.008 4 | 79.73 | 2.58×10-25 | | rs17395349 | 2 | 132439386 | A | G | 0.05 | -0.11 | 0.02 | 2.00×10-6 | GPR39 | 0.001 6 | 15.38 | 7.45×10-6 | | rs1800588 | 15 | 58431476 | T | C | 0.22 | 0.14 | 0.01 | 1.10×10-31 | LIPC | 0.009 8 | 94.84 | 9.27×10-30 | | rs75933914 | 1 | 51296770 | A | G | 0.03 | 0.13 | 0.03 | 8.70×10-6 | TTC39A LOC124904177 | 0.001 4 | 13.63 | 4.65×10-5 | | rs7655751 | 4 | 148712269 | T | C | 0.21 | -0.06 | 0.01 | 8.30×10-7 | LOC107986195 | 0.001 9 | 16.86 | 4.04×10-6 | | rs9393903 | 6 | 11042676 | A | G | 0.23 | 0.08 | 0.01 | 4.00×10-12 | ELOVL2 | 0.003 5 | 33.24 | 3.13×10-10 |
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