两样本孟德尔随机化分析血浆磷脂酰乙醇胺水平与结直肠腺癌发病风险的关系

徐苓, 皇甫昱婵, 沈立松, 马妍慧

Causal association between plasma phosphatidylethanolamine and risk of colorectal adenocarcinoma: a two-sample Mendelian randomization study

XU Ling, HUANGFU Yuchan, SHEN Lisong, MA Yanhui

表2 单一和组合SNP对结直肠腺癌发病风险的影响

Tab 2 Effect of single and combined SNPs on colorectal adenocarcinoma risk

SNP β SE P value rs102275 0.45 0.11 8.01×10-5 rs10781444 0.47 0.44 2.89×10-1 rs1087299 -0.01 0.44 9.87×10-1 rs11254897 0.51 0.43 2.42×10-1 rs1532085 0.13 0.18 4.70×10-1 rs17395349 -0.41 0.53 4.42×10-1 rs1800588 0.07 0.16 6.48×10-1 rs75933914 0.77 0.61 2.01×10-1 rs7655751 0.48 0.50 3.34×10-1 rs9393903 0.82 0.36 2.31×10-2 All IVW 0.31 0.08 7.24×10-5 All MR-Egger 0.36 0.20 1.12×10-1