两样本孟德尔随机化分析血浆磷脂酰乙醇胺水平与结直肠腺癌发病风险的关系

徐苓, 皇甫昱婵, 沈立松, 马妍慧

Causal association between plasma phosphatidylethanolamine and risk of colorectal adenocarcinoma: a two-sample Mendelian randomization study

XU Ling, HUANGFU Yuchan, SHEN Lisong, MA Yanhui

表3 TSMR估计血浆PE相关SNP与结直肠腺癌发生风险的因果关系

Tab 3 Causal relationship between SNPs associated with plasma PE and the risk of colorectal adenocarcinoma estimated by TSMR

Outcome MR method OR (95%CI) P value P value (Cochran′s Q) Colorectal adenocarcinoma IVW 1.36 (1.17‒1.59) 7.24×10-5 0.363 Colorectal adenocarcinoma MR-Egger 1.44 (0.97‒2.14) 1.12×10-1 0.283 Colorectal adenocarcinoma WME 1.33 (1.07‒1.65) 8.81×10-3 ‒ Colorectal adenocarcinoma WM 1.41 (1.12‒1.77) 1.70×10-2 ‒