| Population | Middle-aged and elderly people | Adult | Teenagers and elderly people | / | Middle-aged people | Middle-aged people |
| Oral clinical manifestations | Persistent ulceration with raised margins and necrotic base; indurated on palpation | Oval or round ulcers with a white or yellow pseudomembrane and a surrounding erythematous halo; 1 cm or more in diameter | Frank ulceration is surrounded by a white hyperkeratotic lesion. The location and the shape of the ulcer correspond to the stimulating factor | Deep ulcer with undermined edges and red granular base covered by septic secretion | Ulceration, mass, or necrosis | Necrotic ulceration |
| Location of lesions | The margin of the tongue, and the belly of the tongue | The non-keratinized and keratinized oral mucosa | In a trauma-prone site | Labial mucosa, vestibule, and tongue | Tongue, palate, and buccal mucosa | Median mucosa of the palate |
| Systemic signs | Lymph node swelling, pain, or weight loss | / | / | Cough, anorexia, fatigue, low-grade fever and weight loss | Lymph node swelling, extra-nodal involvement of the gastrointestinal tract and skin, anemia, eosinophilia, or hypergammaglobulinaemia | Nasal mucosal symptoms or B symptoms |
| Clinical course | Persistent | Self-limiting, recurrent, and periodic | Self-limiting | Infection | Aggressive | Aggressive |
Complementary examinations | Biopsy | / | / | Chest X-ray, tuberculin skin test, bacterial culturing | Biopsy, blood test, bone marrow biopsy | Biopsy, blood test, bone marrow biopsy, EBER-ISH |