亚精胺对脂多糖诱导的小鼠颅骨炎症性骨溶解的作用研究

赵心雨, 张文超, 陈旭卓, 宋佳琪, 黄慧, 张善勇

Study on the effects of spermidine on LPS-induced inflammatory osteolysis in mouse calvaria

ZHAO Xinyu, ZHANG Wenchao, CHEN Xuzhuo, SONG Jiaqi, HUANG Hui, ZHANG Shanyong

图5 SPD对RANKL刺激24 h后BMM表达破骨细胞相关基因的影响 Note： A‒D. mRNA levels of Ctsk (A), Ctr (B), Trap (C), and Dcstamp (D). ①P<0.001, ③P=0.001, compared with the control group; ②P<0.001, ④P=0.020, ⑤P=0.018, compared with the RANKL group.

Fig 5 Effects of SPD on the expression of osteoclast-related genes in BMMs after 24 h of RANKL stimulation