磷脂酰乙醇胺引起内质网应激促进巨噬细胞衰老及肝损伤

韩龙传, 李悦, 邹智慧, 罗静, 李若伊, 张颖婷, 唐欣欣, 田丽红, 陆宇恒, 黄莺, 贺明, 付寅坤

Phosphatidylethanolamine promotes macrophage senescence and liver injury by activating endoplasmic reticulum stress

HAN Longchuan, LI Yue, ZOU Zhihui, LUO Jing, LI Ruoyi, ZHANG Yingting, TANG Xinxin, TIAN Lihong, LU Yuheng, HUANG Ying, HE Ming, FU Yinkun

图2 PE处理的衰老巨噬细胞RNA测序功能富集分析 Note： The DOX group was treated with 0.5 μmol·L-1 DOX, while the PE group was treated with 50 μmol·L-1 PE in combination with DOX. A. GO enrichment analysis of cellular component categories, presented as an enrichment factor plot [(PE+DOX) vs DOX]. B. KEGG pathway enrichment analysis displayed as an enrichment factor plot [(PE+DOX) vs DOX]. C. Heatmap of GSVA [(PE+DOX) vs DOX]. D. GSEA of endoplasmic reticulum unfolded protein response and response to endoplasmic reticulum stress [(PE+DOX) vs DOX].

Fig 2 Functional enrichment analysis of RNA sequencing data from senescent macrophages treated with PE