磷脂酰乙醇胺引起内质网应激促进巨噬细胞衰老及肝损伤

韩龙传, 李悦, 邹智慧, 罗静, 李若伊, 张颖婷, 唐欣欣, 田丽红, 陆宇恒, 黄莺, 贺明, 付寅坤

Phosphatidylethanolamine promotes macrophage senescence and liver injury by activating endoplasmic reticulum stress

HAN Longchuan, LI Yue, ZOU Zhihui, LUO Jing, LI Ruoyi, ZHANG Yingting, TANG Xinxin, TIAN Lihong, LU Yuheng, HUANG Ying, HE Ming, FU Yinkun

图4 PE加剧脂多糖诱导的肝损伤 Note： Mice were divided into the PE group, lipopolysaccharide (LPS) group, and PE+LPS group by intraperitoneal injection of PE, LPS, and PE combined with LPS, respectively, with an additional blank control (CTRL) group. A. General morphology, HE staining and immunohistochemistry of the liver from the four groups of mice. HE staining, bar=100 μm; SA-β-gal immunohistochemistry, bar=200 μm; p21 immunohistochemistry, bar=100 μm. Red arrows indicate p21-positive cells. B. Percentages of liver weight. C. Plasma AST in the indicated mice. D. TUNEL staining of liver, bar=50 μm. Red arrows indicate TUNEL-positive cells. ①P<0.001, ②P=0.041, ③P=0.037.

Fig 4 PE exacerbates lipopolysaccharide-induced liver injury