磷脂酰乙醇胺引起内质网应激促进巨噬细胞衰老及肝损伤

韩龙传, 李悦, 邹智慧, 罗静, 李若伊, 张颖婷, 唐欣欣, 田丽红, 陆宇恒, 黄莺, 贺明, 付寅坤

Phosphatidylethanolamine promotes macrophage senescence and liver injury by activating endoplasmic reticulum stress

HAN Longchuan, LI Yue, ZOU Zhihui, LUO Jing, LI Ruoyi, ZHANG Yingting, TANG Xinxin, TIAN Lihong, LU Yuheng, HUANG Ying, HE Ming, FU Yinkun

图5 PE促进肝脏内质网应激、细胞衰老及衰老相关分泌表型基因表达 Note： A. Western blotting analysis of liver lysates from the control (CTRL), PE, LPS, and PE+LPS groups. B‒H. Quantitative real-time PCR analysis of senescence markers and SASP mRNA expression in mouse liver, including p21 (B), p16 (C), Tnf-α (D), Il-6 (E), Il-1β (F), Cxcl1 (G)and Mmp13 (H). ①P=0.019, ②P=0.024, ③P=0.046, ④P=0.002, ⑤P=0.010, ⑥P=0.014, ⑦P=0.003, ⑧P=0.006, ⑨P=0.007, ⑩P=0.008, ⑪P=0.018.

Fig 5 PE promotes the expression of endoplasmic reticulum stress, cellular senescence, and SASP-related genes in the liver