KRAS R68G继发突变引发KRASG12D靶向抑制剂MRTX1133耐药的机制研究

王高明, 崔然, 黎彦璟, 刘颖斌

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin

图2 KRASG12D 和KRASG12D/R68G 的构象动力学 Note： A. The initial structures of the KRASG12D and KRASG12D/R68G systems. B. RMSDs of Cα atoms in KRASG12D and KRASG12D/R68G systems. C. RMSFs of each residue in KRASG12D and KRASG12D/R68G systems. Yellow region stands for the Switch Ⅰ region, while pink region represents the Switch Ⅱ region. D. The distribution of delta RMSF values of the KRASG12D/R68G system relative to the KRASG12D system. Red regions represent higher RMSF values, whereas blue regions stand for lower RMSF values.

Fig 2 Conformational dynamics of KRASG12D and KRASG12D/R68G