KRAS R68G继发突变引发KRASG12D靶向抑制剂MRTX1133耐药的机制研究

王高明, 崔然, 黎彦璟, 刘颖斌

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin

图3 KRAS蛋白的全局构象转变 Note： A. Projections of the first and second principal components (PC1 & PC2) from molecular dynamics simulations of KRASG12D and KRASG12D/R68G systems. B. Conformational changes along PC1.

Fig 3 Global conformational changes of the KRAS protein