KRAS R68G继发突变引发KRASG12D靶向抑制剂MRTX1133耐药的机制研究

王高明, 崔然, 黎彦璟, 刘颖斌

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin

图4 KRAS蛋白的构象景观和代表性构象 Note： A. Characteristic vectors indicating distances of Cα atoms between D12 and P34 (dD12-P34, red dotted line), between D12 and G60 (dD12-G60, blue dotted line), and between P34 and G60 (dP34-G60, yellow dotted line). B. Conformational landscapes generated using the dD12-P34 and dD12-G60 in KRASG12D (blue) and KRASG12D/R68G (red)systems. C. Surface representations of the representative structures in conformational clusters C1 to C4.

Fig 4 Conformational landscape and representative conformations of the KRAS protein