KRAS R68G继发突变引发KRASG12D靶向抑制剂MRTX1133耐药的机制研究

王高明, 崔然, 黎彦璟, 刘颖斌

Study on the mechanism of KRAS R68G secondary mutation-induced resistance to KRASG12D-targeted inhibitor MRTX1133

WANG Gaoming, CUI Ran, LI Yanjing, LIU Yingbin

图5 MRTX1133和GDP的SASA Note： A. Diagram of the SASA of MRTX1133. B. Density plots of SASA of MRTX1133 in KRASG12D and KRASG12D/R68G systems. C. Diagram of the SASA of GDP. D. Density plots of SASA of GDP in KRASG12D and KRASG12D/R68G systems.

Fig 5 SASAs of MRTX1133 and GDP