HENMT1通过激活PI3K-AKT-mTOR信号通路促进胃癌的增殖与迁移

杨娜, 刘俊丽, 白静, 杨思怡, 韩继明, 张华华

HENMT1 promotes the proliferation and migration of gastric cancer by activating the PI3K-AKT-mTOR signaling pathway

YANG Na, LIU Junli, BAI Jing, YANG Siyi, HAN Jiming, ZHANG Huahua

图3 沉默 HENMT1 抑制胃癌细胞的增殖和迁移 Note： A. siHENMT1 efficiency was assessed via Western blotting. B. HENMT1's impact on GC cell viability was evaluated using CCK-8 assay. C. The impact of HENMT1 on clonogenic potential was evaluated through colony formation assay. D/E. Cell scratch and Transwell assay were conducted to analyze HENMT1's influence on cell migration. F. Changes in migration-related proteins were identified using Western blotting. ①P<0.001, ②P=0.002, ③P=0.027, compared with the siNC group.

Fig 3 Silencing HENMT1 inhibits proliferation and migration of GC cells