大黄素改善阿尔茨海默病认知障碍、内质网应激和神经炎症的研究

杨乐, 周怡, 王钶韵, 赖娅莉

Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin

YANG Le, ZHOU Yi, WANG Keyun, LAI Yali

图1 大黄素对AD小鼠认知能力障碍的影响 Note： A. Tracks of the mice in the probe trial. B. Escape latency in the Morris water maze test. C. Number of platform crossings. D. Time spent in the target quadrant. E. Total swimming distance in the target quadrant. 1—Control group, 2—AD group, 3—Emodin 25 mg/kg group, 4—Emodin 50 mg/kg group, 5—Emodin 100 mg/kg group, 6—Donepezil group. ①P<0.001, compared with the control group; ②P=0.015, ③P=0.003, ④P=0.022, ⑤P=0.001, ⑥P=0.038, ⑦P=0.004, ⑧P=0.033, ⑨P=0.007, ⑩P<0.001, compared with the AD group.

Fig 1 Effect of emodin on cognitive impairment in AD mice