大黄素改善阿尔茨海默病认知障碍、内质网应激和神经炎症的研究

杨乐, 周怡, 王钶韵, 赖娅莉

Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin

YANG Le, ZHOU Yi, WANG Keyun, LAI Yali

图2 大黄素对星形胶质细胞激活的影响 Note： A. Immunohistochemical detection of GFAP expression in the mouse cerebral cortex (×400). B. Percentage of GFAP-positive expression. 1—Control group, 2—AD group, 3—Emodin 25 mg/kg group, 4—Emodin 50 mg/kg group, 5—Emodin 100 mg/kg group, 6—Donepezil group. ①P<0.001, compared with the control group. ②P=0.016, ③P=0.002, ④P<0.001, compared with the AD group.

Fig 2 Effect of emodin on the activation of astrocytes