大黄素改善阿尔茨海默病认知障碍、内质网应激和神经炎症的研究

杨乐, 周怡, 王钶韵, 赖娅莉

Research on the improvement of cognitive impairment, endoplasmic reticulum stress and neuroinflammation in Alzheimer's disease by emodin

YANG Le, ZHOU Yi, WANG Keyun, LAI Yali

图3 大黄素对ER应激相关蛋白表达的影响 Note： A. Immunohistochemical staining of GRP78 and IRE1α in mouse cerebral cortex (×400). B. Double immunofluorescence staining of GFAP and GRP78 in mouse brain tissue (×400). C. Percentage of GRP78-positive expression. D. Percentage of IRE1α-positive expression. E. Percentage of GFAP-labeled GRP78+ cells.1—Control group, 2—AD group, 3—Emodin 25 mg/kg group, 4—Emodin 50 mg/kg group, 5—Emodin 100 mg/kg group, 6—Donepezil group. ①P<0.001, compared with the control group. ②P=0.027, ③P=0.005, ④P=0.018, ⑤P=0.002, ⑥P=0.013, ⑦P=0.009, ⑧P<0.001, compared with the AD group.

Fig 3 Effect of emodin on the expression of ER stress-related proteins