不同蛋白结合率抗生素在血液净化中的药代动力学/药效动力学研究

沈玥, 王雨, 徐静仪, 陈渊成, 张菁, 丁峰

Pharmacokinetics/pharmacodynamics of antibiotics with different protein binding rates in hemodialysis

SHEN Yue, WANG Yu, XU Jingyi, CHEN Yuancheng, ZHANG Jing, DING Feng

表1 受试者人口统计学及临床特征

Tab 1 Demographic and clinical characteristics of the study participants

Indicator Meropenem (n=7) Vancomycin (n=5) Ceftriaxone (n=7) P value Age/year 69 (60, 77) 71 (58, 80) 64 (58, 71) 0.198 Male/n(%) 6 (85.7) 5 (100.0) 7 (100.0) 0.059 DWa/kg 66.0 (48.0, 73.5) 58.1 (48.0, 65.0) 63.0 (55.7, 75.0) 0.167 BMI/(kg·m-2) 24.1 (18.8, 27.5) 21.8 (19.2, 25.2) 22.4 (20.5, 25.4) 0.274 eGFRb/[mL·(min·1.73 m2)-1] 10.1 (4.0, 28.0) 7.4 (4.0, 12.0) 9.1 (5.0, 13.0) 0.545 ALT/(U·L-1) 13.6 (6.0, 34.0) 22.8 (7.0, 37.0) 15.4 (3.0, 30.0) 0.492 AST/(U·L-1) 15.6 (8.0, 32.0) 21.8 (12.0, 36.0) 20.7 (6.0, 28.0) 0.273 TP/(g·L-1) 61.9 (49.0, 72.0) 67.4 (62.0, 77.0) 61.6 (49.0, 79.0) 0.325 Alb /(g·L-1) 31.6 (20.0, 38.0) 34.6 (29.0, 40.0) 35.0 (23.0, 42.0) 0.539 HCT 0.278 (0.191, 0.383) 0.288 (0.214, 0.355) 0.276 (0.198, 0.332) 0.866 Qb/(mL·min-1) 212.9 (200.0, 240.0) 218.0 (200.0, 230.0) 217.1 (200.0, 250.0) 0.893 UF/L 2.6 (2.0‒3.5) 2.2 (1.6‒3.3) 2.6 (1.3‒3.3) 0.485