不同蛋白结合率抗生素在血液净化中的药代动力学/药效动力学研究
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沈玥, 王雨, 徐静仪, 陈渊成, 张菁, 丁峰
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Pharmacokinetics/pharmacodynamics of antibiotics with different protein binding rates in hemodialysis
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SHEN Yue, WANG Yu, XU Jingyi, CHEN Yuancheng, ZHANG Jing, DING Feng
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表3 低通量IHD时患者体内抗生素的药代动力学参数
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Tab 3 Pharmacokinetic parameters of antibiotics in patients undergoing low-flux IHD
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| Indicator | Meropenem | Vancomycin | Ceftriaxone |
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| CLdial/(L·h-1) | 4.71±1.10 | 3.25±1.21 | 1.16±0.45 | | CLsys/(L·h-1) | 1.78±0.63 | 0.20±0.13 | 0.27±0.07 | | Vc0/L | 17.60±4.78 | 18.73±1.88 | 10.84±4.79 | | Vp/L | 41.51±12.38 | 32.43±10.53 | 22.42±18.09 | | Q/(L·h-1) | 0.19±0.20 | 0.24±0.25 | 0.25±0.14 | | T1/2on/h | 1.99±0.86 | 11.82±5.10 | 8.16±3.08 | | T1/2off/h | 6.44±3.02 | 50.87±23.62 | 15.46±6.58 | | AUC/(h·mg·L-1) | 278.18±151.80 | 833.19±299.46 | 4262.60±1183.66 | | Vd/L | 18.56±8.97 | 42.19±32.77 | 13.82±7.09 |
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