小菌落变异株的致病机制及治疗研究进展

梁效宁, 石亭旺, 陈云丰

Pathogenic mechanisms and therapeutic advances of small colony variants

LIANG Xiaoning, SHI Tingwang, CHEN Yunfeng

表1 SCV与正常菌株的细胞及菌落形态比较

Tab 1 Comparison of cell and colony morphology between SCVs and normal strains

Colony and cellular morphology SCV NP Colony appearance Small, transparent, needle-like in shape and irregular Round, smooth, with intact edges, convex and glossy Pigmentation Reduced or absent Colorless or colored (varies by species) Hemolytic rings Diameter reduced or absent S. aureus exhibits α- or β-hemolysis Size after 24 h culture Invisible or tiny (1/10 the size of wild-type strains) Visible to the naked eye, 1‒3 mm or larger Special structure PA-SCVs: fewer flagella, increased pil and thicker capsule Normal Cell shape Incomplete, branched and cross-linked Round Cell wall Thickened Relatively thin Cytoplasm Homogeneous Heterogeneous (high peripheral particle density, low central density)