小菌落变异株的致病机制及治疗研究进展

梁效宁, 石亭旺, 陈云丰

Pathogenic mechanisms and therapeutic advances of small colony variants

LIANG Xiaoning, SHI Tingwang, CHEN Yunfeng

表2 纳米颗粒靶向递送抗SCV抗生素的载体类型

Tab 2 Nanocarrier types for targeted delivery of antibiotics against SCVs

Carrier type Delivery vehicle Loaded antibiotic SCV infection model Lipid Nanoparticles Poly lactic-co-glycolic acid (PLGA) nanoparticles[40] Rifampin Murine macrophage Sau-SCV infection model Silica Nanoparticles Mesoporous silica nanoparticles (MSNPs)[41] Rifampin Murine macrophage Sau-SCV infection model Silica Nanoparticles Organically modified (ethylene-bridged) MSNPs (MONs)[42] Rifampin Murine macrophage Sau-SCV infection model Nanogels Dual-responsive nanogels[20] Gentamicin Mouse peritonitis model Nanogels Gelatin-alginate composite nanogels[43] Enrofloxacin Sau-SCV strain Nanogels Chitosan oligosaccharide-carboxymethyl cellulose composite nanogels[44] Tilmicosin Sau-SCV strain Nanogels Composite nanogels[45] Florfenicol Murine mastitis model Nanogels Chitosan composite nanogels[46] Glycyrrhizic acid Sau-SCV strain