SHH激活型髓母细胞瘤中miRNA表达失调的分子机制

朱颖, 隋怡, 唐玉杰

Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma

Zhu Ying, Sui Yi, Tang Yujie

图1 miRNA合成与功能相关的基因在鼠源SHH-MB中的依赖性分析 Note： A. Venn diagram of shared essential genes identified by CRISPR-Cas9 screening under in vitro and in vivo conditions in SmoWT and SMB56 cells. B. Detailed screening results for miRNA biogenesis genes Drosha, Dgcr8, Ago2, Dicer1, and Tarbp2. Genes were ranked by RRA score, which denotes gene essentiality, with lower scores representing stronger essentiality in the negative selection screen. C. Read count changes of sgRNAs targeting Drosha and Dgcr8.

Fig 1 Dependency analysis of miRNA biogenesis genes in mouse SHH-MB models