SHH激活型髓母细胞瘤中miRNA表达失调的分子机制

朱颖, 隋怡, 唐玉杰

Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma

Zhu Ying, Sui Yi, Tang Yujie

图2 鼠源SHH-MB模型与裸鼠正常小脑的mRNA转录组，以及Hh通路转录因子和miRNA生物合成相关基因的mRNA表达水平比较 Note： A. Correlation analysis of mRNA expression profiles across sample groups, including SHH-MB tumors (SmoWT and SMB56 models with or without GDC-0449 treatment) and normal cerebellum (P7 and P60). B/C. Venn diagrams of the overlap of up-regulated mRNAs (B) and down-regulated mRNAs (C) among tumors vs P7 cerebellum, tumors vs P60 cerebellum, and P7 cerebellum vs P60 cerebellum. D. Expression levels of Gli1, Gli2, Drosha, Dgcr8, Tarbp2, Dicer1, Xpo5, and Ago2 in the indicated groups.

Fig 2 Comparison of mRNA transcriptomes between mouse SHH-MB models and normal nude mouse cerebellum, and mRNA expression levels of Hh pathway transcription factors and miRNA biogenesis genes