SHH激活型髓母细胞瘤中miRNA表达失调的分子机制

朱颖, 隋怡, 唐玉杰

Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma

Zhu Ying, Sui Yi, Tang Yujie

图3 鼠源SHH-MB模型与裸鼠正常小脑的miRNA转录组比较及差异表达miRNA的DO富集分析 Note： A. Correlation analysis of miRNA expression profiles across sample groups, including SHH-MB tumors (SmoWT and SMB56 models with or without GDC-0449 treatment) and normal cerebellum (P7 and P60). B/C. Venn diagrams of the overlap of up-regulated miRNAs (B) and down-regulated miRNAs (C) among tumors vs P7 cerebellum, tumors vs P60 cerebellum, and P7 cerebellum vs P60 cerebellum. D/E. DO enrichment analysis of miRNAs consistently up-regulated (D) or down-regulated (E) in both mouse SHH-MB models.

Fig 3 Comparison of miRNA transcriptomes between mouse SHH-MB models and normal nude mouse cerebellum, and DO enrichment analysis of differentially expressed miRNAs