SHH激活型髓母细胞瘤中miRNA表达失调的分子机制

朱颖, 隋怡, 唐玉杰

Molecular mechanisms of miRNA expression dysregulation in SHH-activated subtype medulloblastoma

Zhu Ying, Sui Yi, Tang Yujie

图4 鼠源SHH-MB模型中差异表达miRNAs/mRNAs的Hh通路依赖性及KEGG通路富集分析 Note： A/B. Identification and overlap of Hh-dependent and Hh-independent tumor-upregulated miRNAs and tumor-downregulated mRNAs (A), and tumor-downregulated miRNAs and tumor-upregulated mRNAs (B). C. KEGG enrichment analysis of predicted target genes of Hh pathway-dependent miRNAs/mRNAs. D. Venn diagrams of the overlap of KEGG terms between mouse SHH-MB models in Fig C. cAMP—cyclic adenosine monophosphate; GnRH—gonadotropin-releasing hormone; HIF-1—hypoxia-inducible factor-1; RAS—rat sarcoma viral oncogene; Rap1—ras-related protein 1; DEmiRNAs—differentially expressed miRNAs.

Fig 4 Hh pathway dependence of differentially expressed miRNAs/mRNAs and KEGG pathway enrichment in mouse SHH-MB models